Ogallala Commons is an organization with minimal resources that is attempting to pursue a region-wide triple-bottom line mission while being firmly rooted in the people and communities of the High Plains. The underlying philosophy is complex and far-reaching; its challenge to address the depletion of the High Plains-Ogallala Aquifer is daunting. But there are strong connections to ongoing work in other parts of the country, particularly with those who are pursuing triple-bottom line investment or wealth creation strategies that are built on the sustainable use of local and regional assets. Ogallala Commons is a powerful case study for the Rural Futures Lab as it embraces concepts such as regional collaboration, social equity, entrepreneurship, and the engagement of young people - all with a future orientation towards making the communities of the High Plains sustainable and resilient.